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Alzheimer's Disease

Definition:
Alzheimer's disease is a progressive condition that destroys brain cells and structures. People with Alzheimer's disease slowly lose the ability to learn, function and remember.

Causes:
The cause of Alzheimer's disease is not yet known. Studies suggest that two main mechanisms may result in the clinical picture of the disease:

Plaques - abnormal deposits of a substance called beta amyloid in different areas of the brain

Neurofibrillary Tangles - twisted fibers within nerve cells

Risk Factors:
A risk factor is something that increases your chance of getting a disease or condition.
  • Age: 65 and older
  • Previous serious, traumatic brain injury
  • Lower educational achievement
  • Down's syndrome
  • Down's syndrome in a first-degree relative
  • Women under 35 who give birth to a child with Down's syndrome
  • Smoking
  • Family history of Alzheimer's disease

Researchers are studying the following to see if they are related to Alzheimer's disease:

  • Poor nutrition and vitamin deficiency in childhood
  • Exposure to electromagnetic fields
  • Excess metal in the blood, especially zinc, copper, aluminum, and iron
  • Certain viral infections
Symptoms:
Symptoms of Alzheimer's disease come on gradually. They begin as mild memory lapses, and progress to profound loss of memory and function. Alzheimer's disease is divided into three stages: Early, Intermediate, and Severe.

Symptoms include:

  • Increasing trouble remembering things, such as
    • How to get to familiar places
    • The names of friends and family members
    • Where common objects are usually kept
    • Simple math
    • How to perform tasks, such as cooking, dressing, bathing, etc.
    • Getting lost in familiar surroundings
  • Trouble concentrating on tasks
  • Trouble completing sentences, due to lost or forgotten words (progresses to a complete inability to speak)
  • Difficulty with daily life tasks such as bill paying and house-keeping
  • Inability to remember the date, time of day, season
  • Mood swings
  • Withdrawal, loss of interest in usual activities
  • Slow, shuffling walk
  • Poor coordination
  • Slowness and then loss of purposeful movement
Diagnosis:
The doctor will ask about your symptoms and medical history, and perform a physical exam. There are no tests to definitively diagnose Alzheimer's disease. The doctor will ask many questions to rule out other causes of your symptoms.

Tests to rule out other medical conditions may include:

  • Neurological Exam
  • Psychological and mental status testing
  • CT Scan - a type of x-ray that uses a computer to make pictures of the brain
  • MRI Scan - a test that uses magnetic waves to make pictures of the brain
  • Electroencephalogram (EEG) - a test that measures electrical currents in the brain
  • Blood tests and urine tests
Treatment:
There are no treatments to cure Alzheimer's disease and no certain ways to slow its progression. Four medications have received FDA approval for the treatment of Alzheimer's dementia. Researchers are studying various drugs to see if they can manage the symptoms of Alzheimer's disease or slow its course.Medications for Symptoms and Disease Progression

Medications being used and studied include:

SEE ALSO Dementia

  • Cholinesterase inhibitors
    • o donepezil, rivastigmine, galantamine
  • NMDA receptor antagonist
    • o memantine
  • Anti-oxidants (vitamin E)
  • Estrogen
  • Anti-inflammatory agents
  • Gingko biloba (herbal supplement)
Lifestyle Management

Managing the disease includes:

  • Creating an environment in which you can receive the care you need
  • Optimizing your quality of life
  • Keeping yourself safe
  • Helping yourself learn to deal with the frustration of your uncontrollable behavior
  • Providing a calm, quiet, predictable environment
  • Providing appropriate eyewear and hearing aids, easy-to-read clocks and calendars
  • Playing quiet music
  • Light, appropriate exercise to reduce agitation and relieve depression
  • Encouraging family and close friends to visit frequently
Psychiatric Medications
Medications to treat the psychiatric symptoms that may occur with Alzheimer’s Disease include:
  • Antidepressants - to treat depression
  • Anxiolytics - to treat anxiety
  • Antipsychotics - to treat severe confusion, paranoia, and hallucinations
Caregiver Support
Caring for a person with Alzheimer's disease is extremely difficult and exhausting. The primary caregiver needs emotional support, as well as regular respite.

Prevention:
There are no guidelines for preventing Alzheimer's disease because the cause is unknown.
 
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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